Publications

Journal Articles

Intrinsically robust and scalable biofilm segmentation under diverse physical growth conditions
Chiou, J.G.*, Chou, K.T.*, Garcia-Ojalvo, J., Süel G.M.
(*equal contributors)
iScience, 2024; Vol 27, Issue 12.

Physiological cost of antibiotic resistance: Insights from a ribosome variant in bacteria
Moon, E.C., Modi, T., Lee, D.D., Yangaliev, D.,Garcia-Ojalvo, J., Ozkan, S.B., Süel G.M.
Science Advances, 2024; Vol 10, Issue 46.

Bioelectronic drug-free control of opportunistic pathogens through selective excitability
Kim, S., Eig, E., Yue, J., Yang, A., Comerci C.J, Laune, M., Yang, C., Kamath, A., Shi, J., Li, P., Cheng, Z., Sun, C., Guo, T., Tian, V., Süel G.M., Tian, B.
Device, 2024; 100596.

Bioelectronic tools for understanding the universal language of electrical signaling across species and kingdoms
Shukla, S., Comerci C.J, Süel G.M., Jahed, Z.
Biosensors and Bioelectonics, 2025; Volume 267, 116843.

Bioelectrical delivery of potassium ions controls membrane voltage and growth dynamics in bacteria biofilms
Derchiraju, H., Li, Y., Comerci, C., Luo, L., Figuerres, S., Asefi, N., Trevino, A., Barbee, A., Tebyani, M., Baniya,P., Teodorescu, M., Süel G.M., Rolandi, M.
Biomedical Materials & Devices (2024).

2022

Electrochemical potential enables dormant spores to integrate environmental signals
Kikuchi K.*, Galera-Laporta L.*, Weatherwax C., Lam J.y., Moon E.C., Theodorakis E.A., Garcia-Ojalvo J., Süel G.M.
(*equal contributors)
Science, 2022; Volume 378, Issue 6615, P43-49.

Localized electrical stimulation triggers cell-type-specific proliferation in biofilms
Comerci C.J.*, Gilman A.L.*, Galera-Laporta L., Gutierrez E., Groisman A., Larkin J.W., Garcia-Ojalvo J., Süel G.M.
(*equal contributors)
Cell Systems, 2022; Volume 13, Issue 6, P488-498.E4.

A segmentation clock patterns cellular differentiation in a bacterial biofilm
Chou K.T.*, Lee D.D.*, Chiou J.G.*, Galera-Laporta L., Ly S., Garcia-Ojalvo J., Süel G.M.
(*equal contributors)
Cell, 2022; Volume 185, Issue 1, P145-157.E13.

2021

IonoBiology: The functional dynamics of the intracellular metallome, with lessons from bacteria
Galera-Laporta L.*, Comerci C.J.*, Garcia-Ojalvo J., Süel G.M.
(*equal contributors)
Cell Systems, 2021; Volume 12, Issue 6, 497-508.

2020

Encoding membrane potential-based memory within a microbial community
Yang C.*,Bialecka-Fornal M.*, Weatherwax C., Larkin J.W., Prindle A., Liu J., Garcia-Ojalvo J., Süel G.M.
(*equal contributors)
Cell Systems, 2020; Volume 10, Issue 5, 417-423.
Featured in the Cover

Spiral wave propagation in communities with spatially correlated heterogeneity
Zhai X., Larkin J.W., Süel G.M., and Mugler A.
Biophysical Journal, 2020; Volume 118, Issue 7, 1721-1732.

2019

Statistics of correlated percolation in a bacterial community
Zhai X., Larkin J.W., Kikuchi K., Redford S.E., Roy U., Süel G.M., and Mugler A.
PLoS Comput. Biol., 2019; Volume 15, Issue 12.

Metabolic basis of brain-like electrical signalling in bacterial communities
Martinez-Corral R., Liu J., Prindle A., Süel G.M., and Garcia-Ojalvo J.
Phil. Trans. R. Soc, 2019; Volume 374, Issue 1774.

Magnesium flux modulates ribosomes to increase bacterial survival
Lee D.D.*, Galera-Laporta L.*, Bialecka-Fornal M.*, Moon E.C., Shen Z., Briggs S.P., Garcia-Ojalvo J., and Süel G.M.
(*equal contributors)
Cell, 2019; Volume 177, Issue 2, 352-360.

2018

Bistable emergence of oscillations in growing Bacillus subtilis biofilms
Martinez-Corral R., Liu, J., Süel G.M., and Garcia-Ojalvo J.
Proc Natl Acad Sci U S A., September 4, 2018 115 (36) E8333-E8340;

Signal percolation within a bacterial community
Larkin J.W., Zhai X., Kikuchi K., Redford S.E., Prindle A., Liu J., Greenfield S., Walczak A.M., Garcia-Ojalvo J., Mugler A. and Süel G.M.
Cell Systems, 2018; Volume 7, 1-9.
Featured in the Cover

2017

Snapshot: Electrical communication in biofilms
Lee D.D., Prindle A., Liu J., and Süel G.M.
Cell, 2017; Volume 170, Issue 1, 214-214

Coupling between distant biofilms and emergence of nutrient time-sharing
Liu J., Martinez-Corral R.*, Prindle A.*, Lee D.D., Larkin J., Gabalda-Sagarra M., Garcia-Ojalvo J. and Süel G.M.
(*equal contributors)
Science, 2017; Volume 356, Issue 6338, 638-642

Species-independent attraction to biofilms through electrical signaling
Humphries J., Xiong L., Liu J., Prindle A., Yuan F., Arjes H.A., Tsimring L., and Süel G.M.
Cell, 2017; Volume 168, Issue 1-2, 200-209

2016

Slowdown of growth controls cellular differentiation
Narula J., Kuchina A., Zhang F., Fujita M., Süel G.M., and Igoshin O.A.
Molecular Systems Biology. 2016; 12(5)

Noise expands the response range of the Bacillus subtilis competence circuit
Mugler A.*, Kittisopikul M.*, Hayden L., Liu J., Wiggins C.H., Süel G.M., and Walczak A.M. (*equal contributors)
PLoS Computational Biology. 2016; 12(3)

2015

Ion channels enable electrical communication in bacterial communities
Prindle A., Liu J., Asally M., Ly S., Garcia-Ojalvo J., and Süel G.M.
Nature. 2015; 527(7576)

Metabolic co-dependence gives rise to collective oscillations within biofilms
Liu J., Prindle A.*, Humphries J.*, Gabalda-Sagarra M.*, Asally M.*, Lee D.D., Ly S., Garcia-Ojalvo J., and Süel G.M.
(*equal contributors)
Nature. 2015; 523(7562)

A synthetic quorum sensing system reveals a potential private benefit for public good production in a biofilm
Zhang F., Kwan A., Xu A., and Süel G.M.
PLoS ONE, 2015; 10(7)

Chromosomal arrangement of phosphorelay genes couples sporulation and DNA replication
Narula J., Kuchina A., Lee D.D., Fujita M., Süel G.M., and Igoshin O.A.
Cell, 2015; Volume 162, Issue 2, 328-337
Video Abstract

2013

Inverse Gillespie for inferring stochastic reaction mechanisms from intermittent samples
Chattopadhyay I., Kuchina A., Süel G.M., and Lipson H.
Proc Natl Acad Sci U S A. June 19, 2013 Vol. 110 no. 32 12990-12995

Circuit-level input integration in bacterial gene regulation
Espinar L., Dies M., Çagatay T., Süel G.M., and Garcia-Ojalvo J.
Proc Natl Acad Sci U S A. April 23, 2013 Vol. 110 no. 17 7091-7096

2012

Localized cell death focuses mechanical forces during 3D patterning in a biofilm
Asally M., Kittisopikul M., Rué P., Du Y., Hu Z., Çagatay T., Robinson A.B., Lu H., Garcia-Ojalvo J., and Süel G.M.
Proc Natl Acad Sci U S A. September 24, 2012 Vol. 109 no. 46 18891-18896
Featured as “From The Cover”

Engineered E. coli that detect and respond to gut inflammation through nitric oxide sensing
Archer J.E., Robinson A.B., and Süel G.M.
ACS Synthetic Biology, Publication Date (Web): August 17, 2012

Identification of F-actin as the central hub in a microbial-induced GTPase polarity circuit
Orchard R.C., Kittisopikul M., Altschuler S.J., Wu L.F., Süel G.M. and Alto N.M.
Cell, 2012; Volume 148, Issue 4, 803-815

2011

Temporal competition between differentiation programs determines cell fate choice
Kuchina A., Espinar L., Çagatay T., Balbin A.O., Zhang F., Alvarado A., Garcia-Ojalvo J., and Süel G.M.
Molecular Systems Biology, 2011; (7) Article number: 557
Featured article

Reversible and noisy progression towards a commitment point enables adaptable and reliable cellular decision-making
Kuchina A., Espinar L., Garcia-Ojalvo J., and Süel G.M.
PLoS Computational Biology, 2011; 7(11)

Optimizing periodicity and polymodality in noise-induced genetic oscillators
Rué P., Süel G.M., and Garcia-Ojalvo J.
Physical Review E, 2011; Vol. 83, Issue 6

2010

Biological role of noise encoded in a genetic network motif
Kittisopikul M. and Süel G.M.
Proc Natl Acad Sci U S A. 2010; Vol. 107 no. 30 13300-13305
Featured as “From The Cover”

2009

Capacity of stochastic self-renewal and differentiation in mammalian spermatogonial stem cells
Wu Z., Luby-Phelps K., Bugde A., Molyneux L.A., Denard B., Li W., Süel G.M., and Garbers D.
The Journal of Cell Biology , 2009; Vol. 187 No. 4 : 513-524

Architecture-dependent noise discriminates functionally analogous differentiation circuits
Çagatay T., Turcotte M., Elowitz M.B., Garcia-Ojalvo J. and Süel G.M.
Cell, 2009; Volume 139, Issue 3, 512-522
The Cover Story

2008

A genetic timer through noise-induced stabilization of an unstable state
Turcotte M., Garcia-Ojalvo, J., and Süel G.M.
Proc Natl Acad Sci U S A., 2008; 105(41) : 15732-15737

2007

Tunability and noise dependence in differentiation dynamics
Süel G.M., Kulkami R.P., Dworkin J., Garcia-Ojalvo J., and Elowitz M.B.
Science 2007; 315 (5819) : 1716-1719

2006

An excitable gene regulatory circuit induces transient cellular differentiation
Süel G.M., Garcia-Ojalvo J., Liberman L.M., and Elowitz M.B.
Nature. 2006; 440 (7083) : 545-50

2003

Evolutionarily conserved networks of residues mediate allosteric communication in proteins
Süel G.M., Lockless S.W., Wall M.A., and Ranganathan R.
Nature Structural Biology. 2003; 10 : 59-69

Book Chapters

Chapter III. Title: “Use of Fluorescence Microscopy to Analyze Genetic Circuit Dynamics”
Süel G.M.
Methods in Enzymology, Elsevier Publishing May 2011, Synthetic Biology Part A Volume 497