Publications

Journal Articles

Metabolic basis of brain-like electrical signalling in bacterial communities
Martinez-Corral R., Liu J., Prindle A., Süel G.M., and Garcia-Ojalvo J.
Phil. Trans. R. Soc, 2019; Volume 374, Issue 1774.

Magnesium flux modulates ribosomes to increase bacterial survival
Lee D.D.*, Galera-Laporta L.*, Bialecka-Fornal M.*, Moon E.C., Shen Z., Briggs S.P., Garcia-Ojalvo J., and Süel G.M.
(*equal contributors)
Cell, 2019; Volume 177, Issue 2, 352-360.

Bistable emergence of oscillations in growing Bacillus subtilis biofilms
Martinez-Corral R., Liu, J., Süel G.M., and Garcia-Ojalvo J.
Proc Natl Acad Sci U S A., September 4, 2018 115 (36) E8333-E8340;

Signal percolation within a bacterial community
Larkin J.W., Zhai X., Kikuchi K., Redford S., Prindle A., Liu J.,Greenfield S., Walczak A.M., Garcia-Ojalvo J., Mugler A. and Süel G.M.
Cell Systems, 2018; Volume 7, 1-9.
Featured in the Cover

Snapshot: Electrical communication in biofilms
Lee D.D., Prindle A., Liu J., and Süel G.M.
Cell, 2017; Volume 170, Issue 1, 214-214

Coupling between distant biofilms and emergence of nutrient time-sharing
Liu J., Martinez-Corral R.*, Prindle A.*, Lee D.D., Larkin J., Gabalda-Sagarra M., Garcia-Ojalvo J. and Süel G.M.
(*equal contributors)
Science, 2017; Volume 356, Issue 6338, 638-642

Species-independent attraction to biofilms through electrical signaling
Humphries J., Xiong L., Liu J., Prindle A., Yuan F., Arjes H.A., Tsimring L., and Süel G.M.
Cell, 2017; Volume 168, Issue 1-2, 200-209

Slowdown of growth controls cellular differentiation
Narula J., Kuchina A., Zhang F., Fujita M., Süel G.M., and Igoshin O.A.
Molecular Systems Biology. 2016; 12(5)

Noise expands the response range of the Bacillus subtilis competence circuit
Mugler A.*, Kittisopikul M.*, Hayden L., Liu J., Wiggins C.H., Süel G.M., and Walczak A.M. (*equal contributors)
PLoS Computational Biology. 2016; 12(3)

Ion channels enable electrical communication in bacterial communities
Prindle A., Liu J., Asally M., Ly S., Garcia-Ojalvo J., and Süel G.M.
Nature. 2015; 527(7576)

Metabolic co-dependence gives rise to collective oscillations within biofilms
Liu J., Prindle A.*, Humphries J.*, Gabalda-Sagarra M.*, Asally M.*, Lee D.D., Ly S., Garcia-Ojalvo J., and Süel G.M.
(*equal contributors)
Nature. 2015; 523(7562)

A synthetic quorum sensing system reveals a potential private benefit for public good production in a biofilm
Zhang F., Kwan A., Xu A., and Süel G.M.
PLoS ONE, 2015; 10(7)

Chromosomal arrangement of phosphorelay genes couples sporulation and DNA replication
Narula J., Kuchina A., Lee D.D., Fujita M., Süel G.M., and Igoshin O.A.
Cell, 2015; Volume 162, Issue 2, 328-337
Video Abstract

Inverse Gillespie for inferring stochastic reaction mechanisms from intermittent samples
Chattopadhyay I., Kuchina A., Süel G.M., and Lipson H.
Proc Natl Acad Sci U S A. June 19, 2013 Vol. 110 no. 32 12990-12995

Circuit-level input integration in bacterial gene regulation
Espinar L., Dies M., Çagatay T., Süel G.M., and Garcia-Ojalvo J.
Proc Natl Acad Sci U S A. April 23, 2013 Vol. 110 no. 17 7091-7096

Localized cell death focuses mechanical forces during 3D patterning in a biofilm
Asally M., Kittisopikul M., Rué P., Du Y., Hu Z., Çagatay T., Robinson A.B., Lu H., Garcia-Ojalvo J., and Süel G.M.
Proc Natl Acad Sci U S A. September 24, 2012 Vol. 109 no. 46 18891-18896
Featured as “From The Cover”

Engineered E. coli that detect and respond to gut inflammation through nitric oxide sensing
Archer J.E., Robinson A.B., and Süel G.M.
ACS Synthetic Biology, Publication Date (Web): August 17, 2012

Identification of F-actin as the central hub in a microbial-induced GTPase polarity circuit
Orchard R.C., Kittisopikul M., Altschuler S.J., Wu L.F., Süel G.M. and Alto N.M.
Cell, 2012; Volume 148, Issue 4, 803-815

Temporal competition between differentiation programs determines cell fate choice
Kuchina A., Espinar L., Çagatay T., Balbin A.O., Zhang F., Alvarado A., Garcia-Ojalvo J., and Süel G.M.
Molecular Systems Biology, 2011; (7) Article number: 557
Featured article

Reversible and noisy progression towards a commitment point enables adaptable and reliable cellular decision-making
Kuchina A., Espinar L., Garcia-Ojalvo J., and Süel G.M.
PLoS Computational Biology, 2011; 7(11)

Optimizing periodicity and polymodality in noise-induced genetic oscillators
Rué P., Süel G.M., and Garcia-Ojalvo J.
Physical Review E, 2011; Vol. 83, Issue 6

Biological role of noise encoded in a genetic network motif
Kittisopikul M. and Süel G.M.
Proc Natl Acad Sci U S A. 2010; Vol. 107 no. 30 13300-13305
Featured as “From The Cover”

Capacity of stochastic self-renewal and differentiation in mammalian spermatogonial stem cells
Wu Z., Luby-Phelps K., Bugde A., Molyneux L.A., Denard B., Li W., Süel G.M., and Garbers D.
The Journal of Cell Biology , 2009; Vol. 187 No. 4 : 513-524

Architecture-dependent noise discriminates functionally analogous differentiation circuits
Çagatay T., Turcotte M., Elowitz M.B., Garcia-Ojalvo J. and Süel G.M.
Cell, 2009; Volume 139, Issue 3, 512-522
The Cover Story

A genetic timer through noise-induced stabilization of an unstable state
Turcotte M., Garcia-Ojalvo, J., and Süel G.M.
Proc Natl Acad Sci U S A., 2008; 105(41) : 15732-15737

Tunability and noise dependence in differentiation dynamics
Süel G.M., Kulkami R.P., Dworkin J., Garcia-Ojalvo J., and Elowitz M.B.
Science 2007; 315 (5819) : 1716-1719

An excitable gene regulatory circuit induces transient cellular differentiation
Süel G.M., Garcia-Ojalvo J., Liberman L.M., and Elowitz M.B.
Nature. 2006; 440 (7083) : 545-50

Evolutionarily conserved networks of residues mediate allosteric communication in proteins
Süel G.M., Lockless S.W., Wall M.A., and Ranganathan R.
Nature Structural Biology. 2003; 10 : 59-69

Book Chapters

Chapter III. Title: “Use of Fluorescence Microscopy to Analyze Genetic Circuit Dynamics”
Süel G.M.
Methods in Enzymology, Elsevier Publishing May 2011, Synthetic Biology Part A Volume 497